Advantix® Spot-On Solution is a pharmaceutical product.
Advantix Spot-on Solution is an ectoparasiticide for cutaneous use that contains imidacloprid and permethrin. This association acts as an insecticide, acaricide and repellent. Solution with active substances for spot-on dorsal anointing on the dog's skin; for the prevention and treatment of infestations by fleas (Ctenocephalides canis, Ctenocephalides felis) and for the treatment of chewing lice (Trichodectes canis) infestations in dogs.
For puppies over 8 weeks of age.
Advantix® Spot-On Solution for Dogs are antiparasitic pipettes that are easily applied and provide stress-free treatment for you and your dog.
Advantix® Spot-On Solution for dogs 10 kg to 25 kg at a glance:
Target species: dogs (up to 25 kg in weight)
Advantix® Spot-On Solution for punctual dorsal anointing (spot-on) on the skin of dogs over 8 weeks old and from 10 kg to 25 kg in weight. For dogs weighing more than 25 kg, the appropriate Advantix Spot-on format should be used.
For the prevention and treatment of infestations by fleas (Ctenocephalides canis, Ctenocephalides felis).
Fleas on the dog die during the first 24 hours after the application of the drug.
One treatment prevents further flea infestation for four weeks
The drug can be used as part of a flea allergy dermatitis (FAD) treatment strategy.
For the treatment of chewing lice (Trichodectes canis) infestations.
The drug is effective as a repellent and acaricide against tick infestations (Rhipicephalus sanguineus and Ixodes ricinus for four weeks and Dermacentor reticulatus for three weeks).
By repelling and killing the vector Rhipicephalus sanguineus, the veterinary medicinal product reduces the likelihood of transmission of the Ehrlichia canis pathogen, thereby reducing the risk of canine ehrlichiosis. It has been shown in studies that the risk reduction starts from 3 days after the application of the veterinary medicinal product and persists for 4 weeks.
Ticks already present on the dog may not die within the first two days after treatment, so they may remain attached and visible. Therefore, at the time of treatment it is recommended to remove existing ticks from the dog to prevent blood ingestion.
A treatment has a repellent (anti-feeding) effect against:
sandflies (Phlebotomus papatasi for two weeks and Phlebotomus perniciosus for three weeks)
mosquitoes (Aedes aegypti for two weeks and Culex pipiens for four weeks)
stable fly (Stomoxys calcitrans) for 4 weeks
Reduction of the risk of infection by Leishmania infantum through transmission by sandflies (Phelobotomus perniciosus) for a period of up to 3 weeks. The effect is indirect due to the activity of the veterinary medicinal product against the vector.
The association of both active substances, imidacloprid and permethrin, acts as an insecticide, acaricide and repellent.
In laboratory studies it has been possible to demonstrate that imidacloprid works as an activator of the arthropod ganglia and therefore increases the efficacy of permethrin.
Imidacloprid acts against adult fleas and larval stages
In addition to imidacloprid's adulticidal effect against fleas, its efficacy as a larvicide has been demonstrated in the environment of treated companion animals. Larval stages in the dog's immediate environment are killed as soon as they come into contact with a treated animal.
The drug has a repellent (anti-feeding) effect against ticks, sandflies and mosquitoes, thereby preventing the repelled parasites from ingesting the host's blood. Consequently, the risk of contracting vector-borne diseases in dogs -CVBD- (eg Borreliosis, Rickettsiosis, Ehrlichiosis, Leishmaniosis) is reduced.
However, if the environmental conditions are unfavorable, it could happen that a tick adheres or a mosquito or sandfly bites the animal. For this reason, the transmission of infectious diseases by these parasites cannot be completely excluded. The drug has a repelent (anti-feeding) against the stable fly thus contributing to the prevention of fly-biting dermatitis
Use during pregnancy or lactation:
Advantix® Spot-On Solution can be used during pregnancy and lactation.
In the absence of data, the drug should not be used in puppies less than 7 weeks of age or in dogs weighing less than 1.5 kg.
Do not use in case of hypersensitivity to the active substances or to any of the excipients.
Do not use in cats (see section "Special precautions for use").
Adverse reactions (frequency and seriousness):
Infrequently, itching and hair changes (eg oilier coat) at the site of application and vomiting were observed in clinical studies. On rare occasions, other reactions such as redness, swelling and hair loss at the application site and diarrhea have been reported.
On very rare occasions, reactions such as transient skin sensitivity (rubbing and scratching the skin) or lethargy may be observed in the dog, which were reported in spontaneous reports (pharmacovigilance). These reactions usually resolve spontaneously.
Very rarely, behavioral changes in dogs (agitation, restlessness, growling or whining), gastrointestinal symptoms (hypersalivation, decreased appetite) and neurological signs such as unsteady movements and muscle contraction may be observed in permethrin-susceptible dogs. In general, these signs are temporary and usually resolve spontaneously.
Poisoning in the dog is unlikely to occur after accidental ingestion of the drug, but it can occur in very rare cases. If this is the case, neurological symptoms such as tremors and lethargy may occur. Treatment should be symptomatic. No specific antidote is known.
Do not allow the medicine to come into contact with surface water as the medicine is harmful to fish and aquatic organisms. For treated dogs, see section Special precautions for use.
Medications containing permethrin are toxic to bees.
Read the instructions for this medication and consult your vet or pharmacist.